Howard J. Leonhardt

Howard Leonhardt is an inventor and serial entrepreneur.  He has 21 U.S. patents for products for treating cardiovascular disease.  His TALENT stent graft developed in the early 1990′s holds a leading world market share for repairing aortic aneurysms without surgery.  His inventions have treated over 200,000 patients in 60 countries.  In early 1999 Leonhardt founded Bioheart  a leader in applying adult muscle stem cells to treat heart failure. Leonhardt holds a Diploma in International Trade from Anoka Technical College.  He attended the University of Minnesota and Anoka Ramsey College.  He holds an honorary Doctorate in Biomedical Engineering from the University of Northern California and is an honorary alumnus of the University of Florida and Florida International University.  He is co-leader of Startup California and Founder and Chairman of The California Stock Xchange (Cal-X)  designed to be the first conscious capitalism stock listing service – www.calstockexchange.com – working through multiple partnerships.  Cal-X units include Cal-X Crowdfund Connect www.calxcrowdfund.com, The Cal-X Funders Syndicate and the Cal-Xelerator and Cal-Stars Business Accelerators www.calxstars.com.   Cal-X Stars is a venture creation lab focused on cardiovascular and social good impact innovations.  The lab has brought forward breakthrough innovations in electrical stimulation technologies for directing stem cell therapies, implantable stem cell and circulatory assist pumps and heart valve decalcification catheters.  His Leonhardt Ventures angels network has raised and put to work over $145 million in 28 companies to date, most of them founded by Leonhardt.  Leonhardt serves as state spokesperson in California for the JOBS ACT and Crowdfunding for Startup California and has given over 60 speeches on the subject.  He has signed a contract to co-host the upcoming CNBC TV Series CrowdFund.   He is testing the waters to run in 2018 as a candidate for Lt. Governor of California.

 

Howard Leonhardt is an inventor and serial entrepreneur.  He has 20 U.S. patents for products for treating cardiovascular and heart disease.  These include;  cardiovascular balloon catheters, stent grafts for aneurysm repair, percutaneous heart valves, heart pacemakers with stem cell recruiting capabilities, electrical stimulation devices for promoting blood flow, electrical stimulation device for converting stem cells to heart muscle, stem cell compositions for heart repair, stem cell delivery systems, biological pacemakers and artificial lung catheter.  His TALENT stent graft developed in the early 1990′s holds a leading world market share for repairing aortic aneurysms without surgery.  His inventions have treated over 140,000 patients in 60 countries. In early 1999 Leonhardt founded Bioheart, Inc. www.bioheartinc.com a leader in applying adult muscle stem cells to treat heart failure.  Bioheart has raised over $105 million in paid in capital and additionally $40 million in loans and grants.  Bioheart MyoCell is in Phase II/III clinical trials at 33 leading centers in the USA (The MARVEL Study).  MARVEL Phase II/IIIa part I results were published in the American Heart Journal October of 2011 and demonstrated Bioheart MyoCell patients improved 95.7 meters in exercise capacity over placebo patients receiving optimal CHF drugs, whom declined minus 4 meters.  Leonhardt holds a Diploma in International Trade from Anoka Technical College.  He attended the University of Minnesota and Anoka Ramsey Community College.  He holds an honorary Doctorate in Biomedical Engineering from the University of Northern California and is an honorary alumnus of the University of Florida and Florida International University where he has served on various boards.  He was South Florida Entrepreneur of the Year 2003 and State of Florida Entrepreneur of the Year 2004.  Leonhardt has founded 20 companies to date, most them majority funded by his venture firm Leonhardt Ventures and their associated angel networks www.leonhardtventures.com.  These include;  The California Stock Xchange www.calstockexchange.com, Kindheart Lionheart Adventures www.lionheartadventures.com, MyoStim Pacers www.myostimpacers.com, Leonhardt Vineyards www.leonhardtvineyards.com, Leonhardt’s Launchpads www.leonhardtslaunchpads.com, Kindheart Lionheart Media Co. www.kindheartlionheart.com, Stem Cell Bra www.stemcellbra.com and Wine Country Baseball www.winecountrybaseball.com.  Leonhardt helps lead Startup California www.startupcalifornia.org a region of the Startup America Partnership as a spokesperson on the JOBS ACT and Crowdfunding.   He founded the public policy institute The Entrepreneurship Party www.entrepreneurshipparty.com in 2006 and is an independent candidate for the Governorship of California 2014 http://howardleonhardt.nationbuilder.com/ and www.howardleonhardt.org
Expanded Bio….

Howard Leonhardt is an inventor and serial entrepreneur.  He has 21 patents for products for treating cardiovascular and heart disease.  These include;  cardiovascular balloon catheters, stent grafts for aneurysm repair, percutaneous heart valves, heart pacemakers with stem cell recruiting capabilities, electrical stimulation devices for promoting blood flow, electrical stimulation device for converting stem cells to heart muscle, stem cell compositions for heart repair, stem cell delivery systems, biological pacemakers and artificial lung catheter.  His TALENT stent graft developed in the early 1990’s holds a leading world market share for repairing aortic aneurysms without surgery.  In early 1999 Leonhardt founded Bioheart, Inc. www.bioheartinc.com a leader in applying adult muscle stem cells to treat heart failure.  Bioheart has raised over $105 million in paid in capital and additionally $40 million in loans and grants. Bioheart MyoCell is in Phase II/III clinical trials at 33 leading centers in the USA (The MARVEL Study).  MARVEL Part I results were published in the American Heart Journal October of 2011 and demonstrated Bioheart MyoCell patients improved 95.7 meters in exercise capacity over placebo patients receiving optimal CHF drugs, whom declined minus 4 meters.

Leonhardt has founded 21 companies to date, most them them majority funded by his venture firm Leonhardt Ventures www.leonhardtventures.com,  and their affiliated angel investor network – see web site for full portfolio.  He holds a diploma in International Trade from Anoka Technical College in Minneapolis, Minnesota and attended Anoka-Ramsey College and the University of Minnesota.  He has received an honorary Doctorate in Biomedical Engineering from the University of Northern California and is an honorary alumnus of the University of Florida and Florida International University, where he has served both as a consulting professor teaching entrepreneurship.  He continues to serve on various boards of all three universities.  He has lectured on entrepreneurship at Princeton University, UCLA, the University of Minnesota and at numerous other campuses.

In 1983 he was a founding member of American General Medical Corporation and helped build and equip numerous cardiac cath labs around the globe as Export Sales Manager.  In late 1984 he became Vice President of IMA Medical Group in Fort Lauderdale, Florida.  In 1986 he founded World Medical Corp. a firm that assisted cardiovascular device makers to reach export markets.  World Medical Medical Mfg. Corp. founded 1988 developed over 20 products for cardiovascular disease and grew from a few employees to over 500 before merging with Arterial Vascular Engineering of Santa Rosa, California in April 1998 and subsequently selling to Medtronic Vascular in November 1998.  Leonhardt was voted South Florida Entrepreneur of the Year in 2003 and State of Florida Entrepreneur of the Year in 2004.  Spin outs from Bioheart, Inc. he has founded include MyoStim Pacers www.myostimpacers.com in San Diego, a firm based on his patents for enabling a heart to become self regenerating by recruiting stem cells.  Biopace is a biological pacemaker company in development stage in California.  AortaCell utilizes a cell composition to repair aortic aneurysms.  MyoValve utilizes cells for heart valve repair.  EndoCell uses cells to repair damaged arteries.  Peri-Cell utilizes cells to treat limb ischemia in combination with the electronic MyoStim Limb Blood Flow Stimulator.  Leonhardt is a consultant to BioCell Therapies of Minneapolis that focuses on utilizing stem cells and grafts from fat tissue for breast reconstruction.  Leonhardt serves on the advisory board of the Cell Therapy Foundation and Adult Stem Cell Research Network.

 

Leonhardt’s restaurant Lucille’s Cafe in Weston, Florida www.lucillescafe.com (50% stake with Paul Nunez) has been profitable for nearly a dozen years and is not expanding to food trucks nationwide.

 

Leonhardt Vineyards acquired land in Sonoma County in 2000 and produces Gold Medal winning wines with sales of over 6,000 cases a year to outlets such as Trader Joes in California www.leonhardtvineyards.com. Howard’s son Ryan Leonhardt is now running their wine business.  In 2006 Leonhardt formed The Entrepreneurship Party www.entrepreneurshipparty.com a public policy institute for entrepreneurs and is the author of many related articles.  This organization helped lobby for years for the Crowdfunding and Small Company Capital Formation Acts recently passed by the House of Representatives 407 to 17 and 521-1 with the purpose reducing the costs and complexity for small firms raising capital.

 

He founded in 2008 The California Stock Exchange www.calstockexchange.com, a firm for assisting small firms to raise capital, which is coupled with Leonhardt’s Launchpads www.leonhardtslaunchpads.com his startup business incubator booster program.  Leonhardt owns 12 collegiate summer league baseball teams and the Wine Country Old Fashioned Baseball League www.winecountrybaseball.com which is modeled after the Cape Cod League for college players seeking to get signed into a major league contract.  He previously owned two indoor arena football league teams, the Miami Morays and the Florida Frenzy.

 

In 2011 he started two online radio stations RadioVeronicaUSA www.radioveronicausa.com and RadioSantaMonicaUSA.   His firm Kindheart Lionheart Media Company www.kindheartlionheart.com publishes and retails inspirational books, movies and music.  This includes his own book Dolphin Smiles:  The Legend of Kindheart Lionheart an inspiring fictional tale about a Dolphin that remembers his previous life as a human.  Leonhardt produces regular podcasts of his radio show The Kindheart Lionheart Radio Program which highlights inspiring works and advocates causes for social good entrepreneurs.  Kindheart Lionheart Adventures www.lionheartadventures.com helps organize people to do charity work for others on their vacations, and has adventure packages for auctions to help charitable foundations raise funds.

 

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List of Patent’s by Howard Leonhardt

 

1   7,699,885   Apparatus for engrafting a blood vessel

2   7,686,799   Deployment system for myocardial cellular material

3   7,483,749   Method of enhancing myogenesis by electrical stimulation

4   7,341,062   Method of providing a dynamic cellular cardiac support

5   6,852,116   Method for engrafting a blood vessel

6   6,767,358   Apparatus for engrafting a blood vessel

7   6,690,970   Biological pacemaker and implantation catheter

8   6,572,645   Delivery system for development and endovascular assembly of a multi-stage stented graft

9   6,435,190   Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system

10  6,344,052   Tubular graft with monofilament fibers

11  6,334,869   Endoluminal prosthesis

12  6,280,467   Delivery system for deployment and endovascular assembly of a multi-stage stented graft

13  6,149,575   Radiation delivery catheter

14  5,957,949   Percutaneous placement valve stent

15  5,788,668   Vibrational enhancement of intravenous gas exchanging devices and long-term intravenous devices

16  5,713,917
Apparatus and method for engrafting a blood vessel

17  5,693,029   Pro-cell intra-cavity therapeutic agent delivery device

18  5,591,195   Apparatus and method for engrafting a blood vessel

19  5,522,961   Method of construction of a balloon catheter

20  5,370,618   Pulmonary artery polyurethane balloon catheter

 

 

 

Myoblast transpIantation for heart repair:
A review of the state of the fieId

By Howard J. Leonhardt, Michael Brown

 

E Party from Howard Leonhardt on Vimeo.

www.kindheartlionheart.com

Inspirational books, movies and music – GET INSPIRED!

Autobiographies of Disney, Edison, Jobs and more.  Spiritual texts that bring joy to your heart.

Goal = Lift peoples spirits to do the most with their lives

 

 

www.lionheartadventures.com

Charity vacations and packages to help raise funds for charities

Goal = Encourage people to spend their vacation time giving to people in need fun adventures to be purchased at charitable event auctions = raising money for those in need.

 

 

 

www.LeonhardtVentures.com

 

21 Start-ups and Growing

 

 

www.calstockexchange.com

Helping small companies, musicians, writers, artists and film makers to raise funds to pursue their dreams.  Helping investors find the next great opportunity.

Goal = 23 million new jobs in a decade.  Helping lift the spirit of people and energizing them to be full of joy each day by allowing them to pursue their dreams.

 

 

www.leonhardtslaunchpads.com

Helping small businesses get a good start at less cost.

Goal = 6000 new businesses launched in the next decade.  75% success rate.

 

 

www.nicoleleonhardtfashions.com

Fashion camp for girls and fashion clothes, books and CDs stores

Goal = Use the draw of interest in fashion to teach women’s entrepreneurship and empowerment.  Help people that cannot afford fashion to afford it.

 

 

www.hayleybear.com

Fine wine brokerage specializing in assisting small boutique wineries in Sonoma

Goal = Give the struggling small boutique winery that is ignored by the big distributors a chance to benefit from world class sales and marketing.  Preserve family vineyards.

 

 

www.leonhardtvineyards.com

Fine Sonoma County red wines.  Preserving some of the most beautiful majestic view land in all of California.

Goal = Use wine sales and donations to auctions to raise money for charitable and community causes.  Support local sports.

 

 

www.winecountrybaseball.com

Minor league and collegiate baseball league – 12 teams and expanding.  Affordable family entertainment for Sonoma County.  Development league for young players.

Goals = Help families that cannot afford to go to MLB games in Sonoma County to experience good old fashioned baseball.  Help develop players for MLB.  Help raise monies for local charities and community causes.

 

 

www.entrepreneurshipparty.com

A public policy institute for supporting the causes of entrepreneurs and educators.

Goals = Revive the world economy by promoting the financing of entrepreneurs.  A non-polarizing political movement.  Kindheart Lionheart plan = Kindheart stands for compassion.  Lionheart for courage and economic growth.

 

 

www.bioheartinc.com

Stem cell compositions and methods for heart repair.  The Go To technology partner for heart failure specialists and their patients.

Goals =  Heart failure is the leading economic burden in the U.S. healthcare system costing nearly $80 billion.  Heart Failure will be the cause of death for nearly 13 million people over the next 5 years.  We seek to cut this in half.

 

 

www.artistscafenyc.com

A Cafe promotion company.  We take over a Cafe for a night and line up a series of artists for entertainment and use eCommerce tools to drive attendance.

Goals = Help give struggling artists a chance.  Provide great entertainment to customers.  Raise monies for local charitable causes related to the arts.

 

 

www.lucillescafe.com

Neighborhood family comfort food restaurants.

Goals = Great food.  Great service.  A magical disney like customer experience.  A feeling of being the hometown favorite gathering spot.  Community members.

 

 

www.kindheartlionheart.com/dolphin smiles

Dolphin Smiles:  The Legend of Kindheart Lionheart

An inspirational tale and love story.  Provides spiritual and entrepreneurial life lessons.   We hope to make into an inspiring movie.

Goals = Motivate people to maintain childlike enthusiasm for life throughout their lives.

 

 

www.miamibeachwateradventures.com

A wild dolphin site seeing business and more

Goals = Help people experience the joy of up close contact with free wild dolphins

 

 

Coming soon….www.ebuycalifornia.com and www.ecaliforniastore.com for helping California companies export and also Test Prep Vids www.testprepvids.com quick phone ap to download and view short 3 to 15 minute videos online that students can view right before taking a test to help them prepare and do better on the test

 

TALENT Thoracic Stent Graft

Talent Abdominal Stent Graft With Xcelerant Hydro Delivery System

Clinical Outcomes

TALENT (Taheri-Leonhardt) Stent Graft Brochure

 

 

“The most powerful weapon on earth is the human soul on fire.”

Ferdinand Foch (1851-1929);

French soldier, theorist

Howard J. Leonhardt
hleonhardt@aol.com
www.leonhardtventures.com
Phone 310 310 2534

Howard Leonhardt is an inventor and serial entrepreneur with over 20 patented inventions for treating heart disease.  His inventions have been used to treat more than 200,000 patients to date.  Frustrated with the difficulty and cost in raising capital to develop his inventions he formed The Entrepreneurship Party www.entrepreneurshipparty.com public policy institue in 2006 and began lobbying for reform to reduce the cost and complexity of small firms raising capital.  That led to his alliance with The Startup America Partnership www.s.co where he currently serves as co-state leader for Startup California www.startupcalifornia.org.   His lobbying working with many others helped in small part to lead to The JOBS ACT of 2012.  He was invited to the White House Rose Garden April of 2012 to be with the President as he signed the bill into law.  At that time he was asked to be state spokesperson in California for The Jobs Act and Crowdfunding.  He has since given 34 speeches up and down the state on the subject.   Along the way he has become a vocal advocate of the right to access to capital for women, minorities, youth and the children of middle class families with a particular focus on helping women.  He was a keynote speaker and sponsor at the California Women’s Conference Dolphin Tank Panel this past year.  Leonhardt Ventures has sponsored hundreds of events in California including Google Ventures Startup Labs Startup Sessions, Vator.tv, TedXWomen, Women 2.0, Chic-CEO, Startup Circle, Tech.co, Startup Weekend, BizNow, Silicon Valley Crowdfund, Crowdfunding Bootcamp and CrowdImpact.   He was title partner for CrowdImpact April 23rd, 2013 in Santa Monica “The World’s Largest Social Enterprise Pitch Contest” with over 740 companies participating.  He is an investor in Crowdfunder.com the other title partner for the event.  He is founder and Chairman of The California Stock Exchange www.calstockexchange.com – the first conscious capitalism stock exchange with emphasis on local investing in early registration process with the SEC.  He co-hosted last year GoLocal’s Local Investing tour of Northern California.  He also founded Cal-Xelerator www.calxelerator.com a 12 week startup launch accelerator and Cal-X Stars a 5 year business accelerator with a life science and social good enterprises focus www.calxstars.com.  Spin outs of these organizations include Cal-X Crowdfund Connect www.calxcrowdfund.com a leader in California Equity Crowdfunding, Cal-X Microloans and The Cal-X Funders Club (accredited investor portal).  In 2012 he was recruited by Go Go Luckey Productions to co-host the CNBC TV show CrowdFund:  The American Dream.   He is currently host of The Kindheart Lionheart Radio Show, Lions Den Online TV Show and The Kindheart Lionheart Internet TV Channel.  Leonhardt is also a candidate for Lt. Governor of California for 2014/18 – http://howardleonhardt.nationbuilder.com/howardleonhardt on a promotion of entrepreneurship platform.

 

Patents by Inventor Howard J. Leonhardt
Biological pacemaker and implantation catheter

Patent number: 6690970
Abstract: A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of implantation cells, such as nerve cells, stem cells or ganglion cells, that are introduced into an area of electrical malfunction, such as an impaired SA node or a blocked AV node. The implantation cells grow to form a conductive cell bridge around the malfunction area so that a new pathway is provided for the electrical signals responsible for triggering heart beat contractions. The implantation catheter has a central nerve cell injection needle connected to a syringe or the like via a cell injection tube, and two elongated lateral stabilizing needles. The catheter is inserted into a blood vessel in a patient’s leg, arm, shoulder or the like, and advanced until the catheter’s distal end is located above the malfunction area.
Type: Grant
Filed: October 6, 2000
Issued: February 10, 2004
Inventors: Syde A. Taheri, Howard J. Leonhardt
Deployment system for myocardial cellular material
Patent number: 8308708
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Grant
Filed: February 5, 2010
Issued: November 13, 2012
Assignee: Abbott Cardiovascular Systems Inc.
Inventors: Howard J Leonhardt, Robert D. Lashinski
Apparatus for engrafting a blood vessel
Patent number: 8133267
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Grant
Filed: March 1, 2010
Issued: March 13, 2012
Assignee: Medtronic Vascular, Inc.
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Apparatus for Engrafting a Blood Vessel
Application number: 20100217383
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Application
Filed: March 1, 2010
Issued: August 26, 2010
Assignee: Medtronic Vascular, Inc.
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
DEPLOYMENT SYSTEM FOR MYOCARDIAL CELLULAR MATERIAL
Application number: 20100137835
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Application
Filed: February 5, 2010
Issued: June 3, 2010
Inventors: Howard J. Leonhardt, Robert D. Lashinski
Apparatus for engrafting a blood vessel
Patent number: 7699885
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Grant
Filed: June 30, 2004
Issued: April 20, 2010
Assignee: Medtronic Vascular, Inc.
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Deployment system for myocardial cellular material
Patent number: 7686799
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Grant
Filed: July 13, 2001
Issued: March 30, 2010
Assignee: Abbott Cardiovascular Systems Inc.
Inventors: Howard J Leonhardt, Robert D Lashinski
Method of enhancing myogenesis by electrical stimulation
Patent number: 7483749
Abstract: The present invention provides a method for enhancing regeneration of the myocardium. The method comprises the steps of applying electrical stimulation to an injury site in the myocardium. The method can be used in combination with implantation of myogenic cells into the injury site. The electrical stimulation may be applied before or after the implantation.
Type: Grant
Filed: March 28, 2005
Issued: January 27, 2009
Assignee: Bioheart, Inc.
Inventors: Howard J. Leonhardt, Juan C. Chachques
Method of providing a dynamic cellular cardiac support
Patent number: 7341062
Abstract: The present invention provides a method for repairing damaged myocardium. The method comprises using a combination of cellular cardiomyoplasty and electrostimulation for myogenic predifferentiation of stem cells and to synchronize the contractions of the transplanted cells with the cardiac cells. The method comprises the steps of obtaining stem or myogenic cells from a donor, culturing and electrostimulating the isolated cells in vitro, and implanting the cells into the damaged myocardium.
Type: Grant
Filed: May 17, 2004
Issued: March 11, 2008
Assignee: Bioheart, Inc.
Inventors: Juan C. Chachques, Howard J. Leonhardt
Method for engrafting a blood vessel
Patent number: 6852116
Abstract: A method for deploying an endoluminal prosthesis by introducing into a bifurcated vessel a sheath introducer having therein a bifurcated graft with a primary and contralateral limb. The contralateral limb being radially retained independent of the sheath introducer. The graft being positionable by an insertion catheter. When the graft is in position within the vessel, a retaining device about the contralateral limb is broken and the graft takes the shape of the vessel.
Type: Grant
Filed: February 20, 2002
Issued: February 8, 2005
Assignee: World Medical Manufacturing Corporation
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Apparatus for engrafting a blood vessel
Application number: 20040236403
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Application
Filed: June 30, 2004
Issued: November 25, 2004
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Apparatus for engrafting a blood vessel
Patent number: 6767358
Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
Type: Grant
Filed: September 12, 2001
Issued: July 27, 2004
Assignee: World Medical Manufacturing Corporation
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Biological pacemaker and implantation catheter
Patent number: 6690970
Abstract: A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of implantation cells, such as nerve cells, stem cells or ganglion cells, that are introduced into an area of electrical malfunction, such as an impaired SA node or a blocked AV node. The implantation cells grow to form a conductive cell bridge around the malfunction area so that a new pathway is provided for the electrical signals responsible for triggering heart beat contractions. The implantation catheter has a central nerve cell injection needle connected to a syringe or the like via a cell injection tube, and two elongated lateral stabilizing needles. The catheter is inserted into a blood vessel in a patient’s leg, arm, shoulder or the like, and advanced until the catheter’s distal end is located above the malfunction area.
Type: Grant
Filed: October 6, 2000
Issued: February 10, 2004
Inventors: Syde A. Taheri, Howard J. Leonhardt
Deployment system for myocardial cellular material
Application number: 20040010231
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Application
Filed: July 15, 2003
Issued: January 15, 2004
Inventors: Howard J Leonhardt, Robert D Lashinski
Delivery system for development and endovascular assembly of a multi-stage stented graft
Patent number: 6572645
Abstract: A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the ingrowth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.
Type: Grant
Filed: July 19, 2001
Issued: June 3, 2003
Assignee: Medtronic Ave, Inc.
Inventor: Howard J. Leonhardt
Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
Patent number: 6435190
Abstract: A method of autogenous cell patch cardio myoplasty using noninvasive thoracoscopy is disclosed. A patient’s greater omentum is separated from its point of attachment to either the greater curvature of the stomach or the transverse colon. All open blood vessels in the greater omentum are ligated to permanently arrest bleeding. The greater omentum is introduced into the left pleural cavity through an opening in the diaphragm. Muscle grafts are removed from skeletal muscle tissue of the patient and an opening is formed in the pericardium to expose an area of damaged myocardium. Following attachment of the skeletal muscle grafts to either the greater omentum or the damaged myocardium area, preferably using an advanced muscle graft implantation system, the greater omentum is wrapped around the heart and attached thereto in order to reinforce the muscle grafts and enrich them with blood flow from the greater omentum.
Type: Grant
Filed: June 14, 2000
Issued: August 20, 2002
Inventors: Syde A. Taheri, Howard J. Leonhardt
Method for engrafting a blood vessel
Application number: 20020077634
Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
Type: Application
Filed: February 20, 2002
Issued: June 20, 2002
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Apparatus for engrafting a blood vessel
Application number: 20020065545
Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
Type: Application
Filed: September 12, 2001
Issued: May 30, 2002
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Delivery system for deployment and endovascular assembly of a multi-stage stented graft
Application number: 20020029075
Abstract: A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the ingrowth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.
Type: Application
Filed: July 19, 2001
Issued: March 7, 2002
Assignee: Medtronic AVE, Inc.
Inventor: Howard J. Leonhardt
Endoluminal prosthesis
Patent number: 6334869
Abstract: An apparatus and method for engrafting a blood vessel are disclosed. The apparatus includes a tubular graft having radially compressible annular spring portions for biasing proximal and distal ends of the graft into conforming fixed engagement with an interior surface of the vessel, with bifurcated and adjustable length embodiments being disclosed. Apparatus for deploying the graft includes an insertion catheter having a nitinol core wire, a controllable tip balloon-at a remote end thereof for dilation and occlusion of the vessel, and a controllable graft balloon in the vicinity of the tip balloon for fixedly seating the spring portions into conformance with the interior surface of the vessel. A spool apparatus for adjusting or removing an improperly placed graft, and a micro-emboli filter tube, are usable with the deployment apparatus. A method of percutaneously implanting a graft, including a single-entry method for percutaneously implanting a bifurcated graft, are also disclosed.
Type: Grant
Filed: March 14, 2000
Issued: January 1, 2002
Assignee: World Medical Manufacturing Corporation
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Delivery system for deployment and endovascular assembly of a multi-stage stented graft
Patent number: 6280467
Abstract: A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the in growth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.
Type: Grant
Filed: February 25, 1999
Issued: August 28, 2001
Assignee: World Medical Manufacturing Corporation
Inventor: Howard J. Leonhardt

Radiation delivery catheter
Patent number: 6149575
Abstract: A radiation delivery catheter with inflatable chambers which provide a layer of radiation of minimum effective dose possible to be delivered as close as possible to the origin of disease within a blood vessel. The device can be centered within the true lumen of a vessel to provide even dispersion of the radiation agent to the outer wall of the vessel. The catheter comprises two central self centering balloons, one thin radiation agent inflatable chamber, and one radiation spread cloaking inflatable chamber with high strength properties resistant to rupture.
Type: Grant
Filed: July 7, 1998
Issued: November 21, 2000
Assignee: World Medical Manufacturing Corporation
Inventor: Howard J. Leonhardt
Percutaneous placement valve stent
Patent number: 5957949
Abstract: An artificial valve stent for maintaining patent one way flow within a biological passage is disclosed. The artificial valve includes a tubular graft having radially compressible annular spring portions for biasing proximal and distal ends of the graft into conforming fixed engagement with the interior surface of a generally tubular passage. Also disclosed is a deployment catheter including an inner catheter having a nitinol core wire, a controllable tip balloon at its the distal end for dilation and occlusion of the passage, and a controllable graft balloon in the vicinity of and proximal to the tip balloon for fixedly seating the spring portions in conformance with the interior surface of the passage. A spool apparatus for adjusting or removing an improperly placed or functioning artificial valve, and a microembolic filter tube are usable with the deployment catheter.
Type: Grant
Filed: May 1, 1997
Issued: September 28, 1999
Assignee: World Medical Manufacturing Corp.
Inventors: Howard J. Leonhardt, Trevor Greenan
Vibrational enhancement of intravenous gas exchanging devices and long-term intravenous devices
Patent number: 5788668
Abstract: A method whereby a programmable signal source produces a desired output signal which is transferred by a conduit means or conducting means into a patient by percutaneous venous insertion. The output signal is either vibrational or electrical. If vibrational, the conduit means or one or more transducers radiates the output signal into the treatment site within a patient. If electrical, one or more transducers receive the output signal and convert the output signal into vibration and then radiate it into the treatment site within a patient. The treatment site is the location of a catheter or other intravenous device, residing within the patient for the purposes of gas exchange in the blood stream or for other long-term treatment. The presence of the vibration increases the efficiency of intravenous gas exchanging devices significantly, and prevents clot formation on the surface of intravenous devices.
Type: Grant
Filed: May 9, 1996
Issued: August 4, 1998
Assignee: World Medical Manufacturing Corporation
Inventor: Howard J. Leonhardt
Apparatus and method for engrafting a blood vessel
Patent number: 5713917
Abstract: An apparatus and method for engrafting a blood vessel are disclosed. The apparatus includes a tubular graft having radially compressible annular spring portions for biasing proximal and distal ends of the graft into conforming fixed engagement with an interior surface of the vessel, with bifurcated and adjustable length embodiments being disclosed. Apparatus for deploying the graft includes an insertion catheter having a nitinol core wire, a controllable tip balloon at a remote end thereof for dilation and occlusion of the vessel, and a controllable graft balloon in the vicinity of the tip balloon for fixedly seating the spring portions into conformance with the interior surface of the vessel. A spool apparatus for adjusting or removing an improperly placed graft, and a micro-emboli filter tube, are usable with the deployment apparatus. A method of percutaneously implanting a graft, including a single-entry method for percutaneously implanting a bifurcated graft, are also disclosed.
Type: Grant
Filed: September 18, 1996
Issued: February 3, 1998
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Pro-cell intra-cavity therapeutic agent delivery device
Patent number: 5693029
Abstract: A flexible and kink-proof intra-cavity delivery catheter for precise placement and injection of therapeutic agent(s) into and/or through the wall of a body cavity at a precise treatment site with even distribution throughout. One or more needle assemblies are disposed around a calibrated balloon which, when inflated, brings each needle assembly into contact with and enables the piercing of the cavity wall to a calibrated depth. Each needle assembly consists of a plurality of tissue insertion needles along the longitudinal axis of the needle assembly. Precise amounts of the therapeutic agent are then quickly delivered through the needle assembly directly into the diseased body tissue. When the calibrated balloon is deflated, retraction members pull the needle assemblies back into the catheter body for catheter repositioning or catheter withdrawal.
Type: Grant
Filed: July 10, 1995
Issued: December 2, 1997
Assignee: World Medical Manufacturing Corporation
Inventor: Howard J. Leonhardt
Method for inducing angiogenesis by electrical stimulation of muscles
Application number: 20060041286
Abstract: The present invention discloses a method for angiogenesis. The method comprises the steps of electrically stimulating a muscle below the threshold for muscle contraction.
Type: Application
Filed: October 25, 2005
Issued: February 23, 2006
Inventors: Shinichi Kanno, Yasufumi Sato
Method for inducing angiogenesis by electrical stimulation of muscles
Application number: 20020031827
Abstract: The present invention discloses a method for angiogenesis. The method comprises the steps of electrically stimulating a muscle below the threshold for muscle contraction.
Type: Application
Filed: May 15, 2001
Issued: March 14, 2002
Inventors: Shinichi Kanno, Yasufumi Sato
Method for inducing angiogenesis by electrical stimulation of muscles
Patent number: 6988004
Abstract: The present invention comprises a method for stimulating angiogenesis. The method comprises the steps of electrically stimulating muscle below the threshold for muscle contraction.
Type: Grant
Filed: May 15, 2001
Issued: January 17, 2006
Assignee: Bioheart, Inc.
Inventors: Shinichi Kanno, Yasufumi Sato

Apparatus and method for engrafting a blood vessel
Patent number: 5591195
Abstract: A method and apparatus for engrafting a blood vessel is disclosed. The apparatus includes a hollow tubular graft of a preselected cross section having a proximal and distal end containing compressable and expandable nitinol springs, and connecting bars to facilitate physical communication between both springs. Furthermore, the apparatus contains a transport and deployment member for delivering said hollow tublar graft to an engrafting site within a blood vessel. The transport and deployment apparatus is comprised of an insertion catheter having a graft balloon and a tip balloon, as well as multiple inner tracks for injection of fluid into said balloons and the blood vessel interior. The method includes transport and deployment of said graft, as well as non surgical movement and removal of said graft in the event of misplacement.
Type: Grant
Filed: October 30, 1995
Issued: January 7, 1997
Inventors: Syde Taheri, Howard J. Leonhardt
Method of construction of a balloon catheter
Patent number: 5522961
Abstract: The method of manufacturing a polyurethane balloon catheter from a length of tubing of such material wherein the tubing is placed in a mold of the desired final expanded shape, the mold and tubing are immersed in a bath of warm water, and air pressure is introduced into the tubing to effect the expansion and then withdrawn to allow the removal of the balloon.
Type: Grant
Filed: October 19, 1994
Issued: June 4, 1996
Assignee: World Medical Corporation
Inventor: Howard J. Leonhardt
Method of providing a biological pacemaker
Patent number: 5103821
Abstract: A process for providing a biological pacemaker for the human heart wherein the sino-atrial (S-A) node cells are removed from the heart and cultured to generate a critical mass of S-A node cells of sufficient quantity to generate a depolarization wave capable of stimulating the cells of the myocardium to ensure normal or near-normal pumping action in the heart. The critical mass of S-A node cells are then implanted in the myocardial tissue of the right ventricle to provide biological pacing for the heart which is sensitive to and variable with normal increase and decrease of output demands on the heart.
Type: Grant
Filed: November 30, 1990
Issued: April 14, 1992
Assignee: Angeion Corporation
Inventor: Wendell L. King

Pulmonary artery polyurethane balloon catheter
Patent number: 5370618
Abstract: A self centering, low profile, low inflation pressure pulmonary artery polyurethane balloon catheter having a reduced neck section and a balloon disposed within the neck section such that the balloon is flush with the catheter body in the deflated state and extends beyond the distal end of the catheter in both its inflated and deflated states.
Type: Grant
Filed: November 20, 1992
Issued: December 6, 1994
Assignee: World Medical Manufacturing Corporation
Inventor: Howard J. Leonhardt

 

Proud member Center for Technology & Innovation in Pediatrics Advisory Board for Children’s Hospital Los Angeles – Howard J. Leonhardt  http://www.scctip.com/about/advisory-board/

 

Debate between advocates and opponents of equity crowdfunding at Crowdfunding California Conference in Berkeley. Participants:

Life Saver Howard Leonhardt Interview Startups

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